Engineering Cell Factories
Refine Biology leverages six synthetic biology engineering platforms—from gene editing and directed evolution to fermentation and purification—to build high-performance microbial cell factories. Our vertically integrated technology system accelerates the development and industrial-scale production of natural functional ingredients.
Enzyme Engineering Platform
Enzyme Engineering Platform
Our platform specializes in the rational and semi-rational design and engineering of industrial enzymes and key synthetic biology components. Using homology modeling, molecular dynamics simulations, and AI-assisted protein design tools, we precisely identify critical residues affecting enzyme activity, stereoselectivity, and stability. We intelligently construct mutant libraries and leverage high-throughput screening to deliver a full workflow from sequence prediction and computational design to functional validation.
Computational & AI Enzyme Design
Leveraging homology modeling, dynamics simulation, and AI prediction tools
Precision Site Identification
Intelligently targeting and constructing mutant libraries affecting activity and selectivity
Resilience & Efficiency Breakthroughs
Rapidly achieving non-natural substrate adaptation and catalytic leaps
Full Workflow Validation
Bridging "sequence-computation-validation" for high-performance enzyme development