Engineering Cell Factories
Refine Biology leverages six synthetic biology engineering platforms—from gene editing and directed evolution to fermentation and purification—to build high-performance microbial cell factories. Our vertically integrated technology system accelerates the development and industrial-scale production of natural functional ingredients.
High-Throughput Screening & Directed Evolution Platform
High-throughput Screening & Directed Evolution Platform
Our platform integrates DREM cell/MISS cell high-throughput droplet single-cell sorting, automated microplate screening, fully automated microbial evolution, mutant library construction, and AI-assisted mutation prediction. We rapidly screen high-yield, stress-tolerant, substrate-inhibition-resistant, and high-conversion-rate superior strains from massive mutant libraries and rationally engineered strains.
High-Throughput Single-Cell Sorting
DREM/MISS cell droplet and microplate rapid screening
Automated Evolutionary Breeding
Fully automated microbial evolution and library construction system
AI-Assisted Mutation Prediction
Rational engineering and intelligent strain performance design
Targeted Strain Optimization
Efficient iterative upgrading of high-yield stress-tolerant superior strains
(10M–100M/Day)
(10,000×)
(106× Reduction)