Refine Tech Ecosystem
Engineering Cell Factories
Refine Biology leverages six synthetic biology engineering platforms—from gene editing and directed evolution to fermentation and purification—to build high-performance microbial cell factories. Our vertically integrated technology system accelerates the development and industrial-scale production of natural functional ingredients.
Technology Platform 02
Eukaryotic Microbial Gene Editing Platform
Eukaryotic Microbial Gene Editing Platform
Targeting industrial eukaryotic chassis such as Saccharomyces cerevisiae and Pichia pastoris, our platform integrates efficient CRISPR/Cas9 systems with homology-directed repair technology. We achieve efficient multi-site genomic integration, precise metabolic pathway regulation, and targeted long-fragment integration at high-expression loci. Our strain rejuvenation and genetic stability assurance processes enable high expression and stability of natural products, recombinant proteins, and organic acids in eukaryotic cell factories.
CRISPR/Cas9 System
Efficient homology-directed repair technology
Targeted Long-Fragment Integration
Precise multi-site integration at high-expression loci
Metabolic Pathway Regulation
Precise eukaryotic gene expression and regulation system
Genetic Stability Assurance
Stable strain rejuvenation and high-yield eukaryotic factory processes