Engineering Cell Factories
Refine Biology leverages six synthetic biology engineering platforms—from gene editing and directed evolution to fermentation and purification—to build high-performance microbial cell factories. Our vertically integrated technology system accelerates the development and industrial-scale production of natural functional ingredients.
Prokaryotic Microbial Gene Editing Platform
Prokaryotic Microbial Gene Editing Platform
Focused on prokaryotic chassis such as Escherichia coli and Bacillus subtilis, our platform integrates CRISPR/Cas9 precise cleavage with homologous recombination, base editing, and transposon insertion tools. We enable large-fragment gene cluster knock-in, multi-site synchronous editing, and batch construction of engineered strains for producing terpenoids, organic acids, amino acids, and more.
Genome Editing System
High-throughput and high-efficiency editing platform
Multi-Function Toolkit
Integrating recombination, base editing, and transposon tools
Multi-Site Synchronous Editing
Scarless knock-in and modification of large gene clusters
Prokaryotic Cell Factories
Batch construction of engineered strains for terpenoids and organic acids